How to remove rootkits by hand

How to remove rootkits by hand: "Manually removing rootkit-based malware can be extremely difficult. You cant delete the offending Registry entries because the malware process is running. You halt the malware process, but Windows restarts the malware before you can delete the Registry entries. Many rootkits also set the Registry entries’ owner to someone other than the user, thus complicating things further."

(Via Computerworld Breaking News.)